A Cancer Stem Cell Potent Copper(II) Complex with a <i>S</i> , <i>N</i> , <i>S</i> ?Schiff base Ligand and Bathophenanthroline
نویسندگان
چکیده
We investigate the anti-cancer stem cell (CSC) properties of two copper(II) complexes containing 4,7-diphenyl-1,10-phenanthroline and a S, N, X-Schiff base ligand, where X=O (1) or S (2). Complex 1 was previously reported by us, is first metal complex to induce cytotoxic immunogenic death breast CSCs. 2 structural analogue 1, phenolate moiety (within Schiff ligand) replaced thiophenolate group. kills bulk cancer cells CSCs in sub-micromolar range, with reduced toxicity towards non-cancerous epithelial cells. Remarkably, over 10-fold more potent CSC spheroids than salinomycin (an established anti-breast agent) cisplatin (a clinically approved anticancer drug). readily enters CSCs, accumulates cytosol, increases intracellular reactive oxygen species (ROS) levels upon short exposure (1 h). The latter likely be mechanism which induces death.
منابع مشابه
Experimental and theoretical characterization of a new Schiff-base ligand
Here, new N,N′-dipyridoxyl(4,4''-diaminodiphenylether) Schiff-base ligand has been synthesized and characterized by IR, 1H NMR and mass spectrometry. Also, geometry optimization and theoretical assignment of IR spectrum of the ligand have been computed by employing density functional theory (DFT) method. Two pyridine rings and benzene rings in the bridge region are not in the same plane. The ca...
متن کاملStudy the Interaction of Ni Complex of Tetradentate Schiff Base Ligand with HEN Egg White Lysozyme
AbstractInteraction of Ni complex(Salen= N, N´-ethylene bis(salicylideneimine)) with hen egg-white lysozyme (HEWL) was studied by absorption spectroscopy, competitive binding study and thermal denaturation study. The protein binding affinity of Ni complex was found to be (3.0×103M−1). The binding plot obtained from the absorption titration data gives a binding constant of 2.4 (± 0.3)×103 M...
متن کاملIranian ISI and Non-ISI Medical Research Articles in English: A Comparative ESP/EAP Move Analysis*
During recent decades publishing articles in academic journals has become a worldwide urge for all members of academia. There is, however, a widespread belief according to which more value is given to the articles published in internationally-recognized, high standard journals. An issue raised in this regard is whether the articles published in highly prestigious journals are remarkably d...
متن کاملSynthesis and Characterization of Binuclear Zn(II) Complex of N2O2S Symmetrical Potentially Pentadentate Schiff Base Ligand
The reactions of 1 - chloro - 2 - nitro benzene with 2 - Amino thio phenol yield the 2 - ( ( nitro phenyl ) thio ) aniline and then 2 , 2' - thio dianiline of this compound was prepared . Also the symmetrical potentially pentadentate N 2 O 2 S Schiff base ligand 2 , 2' - ( ( ( thio bis (1 , 2 - phenylene ) ) bis ( azanilidene ) ) bis ( methenilidene ) ) diphenol ( H 2 L ) obtain by added salicy...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Inorganic Chemistry
سال: 2021
ISSN: ['1434-1948', '1099-0682']
DOI: https://doi.org/10.1002/ejic.202100125